Detail Lymphotoxin pReceptor-Dependent Control of Lipid Homeostasis   Oleh:  Lo, James C. ; Wang, Yugang ; Tumanov, Alexei V. ; Bamji, Michelle ; Yao, Zemin ; Reardon, Catherine A. ; Getz, Godfrey S. ; Fu, Yang-Xin Jenis: Article from Bulletin/Magazine Dalam koleksi: SCIENCE (keterangan: ada di Proquest) vol. 316 no. 5822 (Apr. 2007), page 285. Ketersediaan Perpustakaan FK Nomor Panggil: S01.K.2007.04 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada     Lihat Detail Induk Isi artikel Hyperlipidemia, one of the most important risk factors for coronary heart disease, is often associated with inflammation. We identified lymphotoxin (LT) and LIGHT, tumor necrosis factor cytokine family members that are primarily expressed on lymphocytes, as critical regulators of key enzymes that control lipid metabolism. Dysregulation of LIGHT expression on T cells resulted in hypertriglyceridemia and hypercholesterolemia. In low-density lipoprotein receptor-deficient mice, which lack the ability to control lipid levels in the blood, inhibition of LT and LIGHT signaling with a soluble lymphotoxin ~ receptor decoy protein attenuated the dyslipidemia. These results suggest that the immune system directly influences lipid metabolism and that LT modulating agents may represent a novel therapeutic route for the treatment of dyslipidemia. Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Kembali

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