Detail Evolutionary Formation of New Centromeres in Macaque   Oleh:  Ventura, Mario ; Antonacci, Francesca ; Cardone, Maria Francesca ; Stanyon, Roscoe ; Addabbo, Pietro ; Cellamare, Angelo ; Sprague, L. James ; Eichler, Evan E ; Archidiacono, Nicoletta ; Rocchi, Mariano Jenis: Article from Bulletin/Magazine Dalam koleksi: SCIENCE (keterangan: ada di Proquest) vol. 316 no. 5822 (Apr. 2007), page 243. Ketersediaan Perpustakaan FK Nomor Panggil: S01.K.2007.04 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada     Lihat Detail Induk Isi artikel A systematic fluorescence in situ hybridization comparison of macaque and human synteny organization disclosed five additional macaque evolutionary new centro meres (ENCs) for a total of nine ENCs. To understand the dynamics of ENC formation and progression, we compared the ENC of macaque chromosome 4 with the human orthologous region, at 6q24.3, that conserves the ancestral genomic organization. A 250-kilobase segment was extensively duplicated around the macaque centromere. These duplications were strictly intrachromosomal. Our results suggest that novel centro meres may trigger only local duplication activity and that the absence of genes in the leeding region may have been important in ENC maintenance and progression. Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Kembali

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