Detail Demographic Histories and Patterns of Linkage Disequilibrium in Chinese and Indian Rhesus Macaques   Oleh:  Hernandez, Ryan D ; Hubisz, Melissa J ; Wheeler, David A ; Smith, David G. ; Ferguson, Betsy ; Rogers, Jeffrey ; Nazareth, Lynne ; Indap, Amit ; Bourquin, Traci ; McPherson, John ; Muzny, Donna ; Gibbs, Richard ; Nielsen, Rasmus ; Bustamante, Carlos D Jenis: Article from Bulletin/Magazine Dalam koleksi: SCIENCE (keterangan: ada di Proquest) vol. 316 no. 5822 (Apr. 2007), page 240. Ketersediaan Perpustakaan FK Nomor Panggil: S01.K.2007.04 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada     Lihat Detail Induk Isi artikel To understand the demographic history of rhesus macaques (Macaca mulatta) and document the extent of linkage disequilibrium (LD) in the genome, we partially resequenced five Encyclopedia of DNA Elements regions in 9 Chinese and 38 captive-born Indian rhesus macaques. Population genetic analyses of the 1467 single-nucleotide polymorphisms discovered suggest that the two populations separated about 162,000 years ago, with the Chinese population tripling in size since then and the Indian population eventually shrinking by a factor of four. Using coalescent simulations, we confirmed that these inferred demographic events explain a much faster decay of LD in Chinese (? .. 0.15 at 10 kilo bases) versus Indian (? .. 0.52 at 10 kilobases) macaque populations. Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Kembali

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