Detail A Conserved Family of Enzymes That Phosphorylate Inositol Hexakisphosphate   Oleh:  Mulugu, Sashidhar ; Bai, Wenli ; Fridy, Peter C ; Bastidas, Robert J ; Otto, James C. ; Haystead, Timothy A. ; Ribeiro, Anthony A. ; York, John D. Jenis: Article from Bulletin/Magazine Dalam koleksi: SCIENCE (keterangan: ada di Proquest) vol. 316 no. 5821 (Apr. 2007), page 106. Ketersediaan Perpustakaan FK Nomor Panggil: S01.K.2007.04 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada     Lihat Detail Induk Isi artikel Inositol pyrophosphates are a diverse group of high-energy signaling molecules whose cellular roles remain an active area of study. We report a previously uncharacterized class of inositol pyrophosphate synthase and find it is identical to yeast Vipl and Aspl proteins, regulators of actin-related protein-2/3 (ARP 2/3) complexes. Vipl and Aspl acted as enzymes that encode inositol hexakisphosphate (JP6) and inositol heptakisphosphate (JP7) kinase activities. Alterations in kinase activity led to defects in cell growth, morphology, and interactions with ARP complex members. The functionality of Aspl and Vipl may provide cells with increased signaling capacity through metabolism of IP6. Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Kembali

Copyright © 2006, 2007 Unika Atma Jaya, all rights reserved