Detail Acid Catalysis in Basic Solution: A Supramolecular Host Promotes Orthoformate Hydrolysis   Oleh:  Pluth, Michael D. ; Bergman, Robert G. ; Raymond, Kenneth N. Jenis: Article from Bulletin/Magazine Dalam koleksi: SCIENCE (keterangan: ada di Proquest) vol. 316 no. 5821 (Apr. 2007), page 85. Ketersediaan Perpustakaan FK Nomor Panggil: S01.K.2007.04 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada     Lihat Detail Induk Isi artikel Although many enzymes can promote chemical reactions by tuning substrate properties purely through the electrostatic environment of a docking cavity, this strategy has proven challenging to mimic in synthetic host-guest systems. Here, we report a highly charged, water-soluble, metal¬ligand assembly with a hydrophobic interior cavity that thermodynamically stabilizes protonated substrates and consequently catalyzes the normally acidic hydrolysis of orthoformates in basic solution, with rate accelerations of up to 890-fold. The catalysis reactiol] obeys Michaelis-Menten ~inetics and exhibits competitive inhibition, and the substrate scope displays size selectivity, consistent with the constrained binding environment of the molecular host. Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Kembali

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