Transfusion Strategies for Patients in Pediatric Intensive Care Units  

Oleh:

Hebert, Paul C ; Lacroix, Jacques ; Hutchison, James S. ; Hume, Heather A ; Tucci, Marisa ; Ducruet, Thierry ; Gauvin, France ; Collet, Jean-paul ; Toledano, Baruch J. ; Robillard, Pierre ; Joffe, Ari ; Biarent, Dominique ; Meert, Kathleen ; Peters, Mark J.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The New England Journal of Medicine (keterangan: ada di Proquest) vol. 356 no. 16 (Apr. 2007), page 1609.

Ketersediaan

Perpustakaan FK Nomor Panggil: N08.K.2007.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

BACKGROUND The optimal hemoglobin threshold for erythrocyte transfusions in critically ill chil¬dren is unknown. We hypothesized that a restrictive transfusion strategy of using packed red cells that were leukocyte-reduced before storage would be as safe as a lib¬eral transfusion strategy, as judged by the outcome of multiple-organ dysfunction. METHODS In this noninferiority trial, we enrolled 637 stable, critically ill children who had he¬moglobin concentrations below 9.5 g per deciliter within 7 days after admission to an intensive care unit. We randomly assigned 320 patients to a hemoglobin threshold of7 g per deciliter for red-cell transfusion (restrictive-strategy group) and 317 patients to a threshold of 9.5 g per deciliter (liberal-strategy group). RESULTS Hemoglobin concentrations were maintained at a mean (:tSD) level that was 2.1:t0.2 g per deciliter lower in the restrictive-strategy group than in the liberal-strategy group (lowest average levels, 8.7:tOA and 10.8:t0.s g per deciliter, respectively; P

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