Detail RAPBO Targets BRCA1 to Specific Ubiquitin Structures at DNA Damage Sites   Oleh:  Sobhian, Bijan ; Shao, Genze ; Lilli, Dana R. ; Culhane, Aedin C ; Moreau, Lisa A. ; Xia, Bing ; Livingston, David M. ; Greenberg, Roger A. Jenis: Article from Bulletin/Magazine Dalam koleksi: SCIENCE (keterangan: ada di Proquest) vol. 316 no. 5828 (May 2007), page 1198. Ketersediaan Perpustakaan FK Nomor Panggil: S01.K.2007.05 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada     Lihat Detail Induk Isi artikel Mutations affecting the BRCT domains of the breast cancer-associated tumor suppressor BRCA1 disrupt the recruitment of this protein to DNA double-strand breaks (DS~s). The molecular . structures'at DSBs recognized by BRCA1 are presently unknown. We report the interaction of the BRCA1 BRCT domain with RAP80, a ubiquitin~binding protein. RAP80 targets a complex containing the BRCA1-BARD1 (BRCA1-associated ring domain protein 1) E3 ligase and the deubiquitinating enzyme (DUB) BRCC36 to MDCl-yH2AX-dependent lysine6- and lysine63-linked ubiquitin polymers at DSBs. These events are required for cell cycle checkpoint and repair responses to ionizing radiation, implicating ubiquitin chain recognition and tumoverin the BRCA1-mediated repair of DSBs. Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Kembali

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