Detail Regulation of NF-KB Activation in T Cells via Association of the Adapter Proteins ADAP and CARMA1   Oleh:  Medeiros, Ricardo B. ; Burbach, Brandon J ; Mueller, Kristen L. ; Srivastava, Rupa ; Moon, James J. ; Highfill, Sarah ; peterson, Erik J. ; Shimizu, Yoji Jenis: Article from Bulletin/Magazine Dalam koleksi: SCIENCE (keterangan: ada di Proquest) vol. 316 no. 5825 (May 2007), page 754. Topik: Immunology Ketersediaan Perpustakaan FK Nomor Panggil: S01.K.2007.05 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada     Lihat Detail Induk Isi artikel The adapter protein ADAP regulates T lymphocyte adhesion and activation. We present evidence for a previously unrecognized function for ADAP in regulating T .cell receptor (TCR)-mediated activation of the transcription factor NF-KB. Stimulation of ADAP-defident mouse T cells with antibodies to CD3 and CD28 resulted in impaired nuclear translocation of NF-KB, a reduced DNA binding, and delayed degradation and decreased phosphorylation of IKB (inhibitor of NF-KB). TCR-stimulated assembly of the CARMA1-BCL-10-MALT1 complex was substantially impaired in the absence of ADAP. We further identified a region of ADAP that is required for assodation with the CARMA1 adapter and NF-KB activation but is not required for ADAP-dependent regulation of adhesion. These findings provide new insights into ADAP function and the mechanism by which CARMAlregulates NF-KB activation in T cells. Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Kembali

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