Detail Reducing Endogenous Tau Ameliorates Amyloid B-Induced Deficits in an Alzheimer's Disease Mouse Model   Oleh:  Roberson, Erik D. ; Scearce-levie, Kimberly ; Palop, Jorge J. ; Yan, Fengrong ; Cheng, Irene H. ; WU, Tiffany ; Gerstein, Hilary ; Yu, Gui-Qiu ; Mucke, lennart Jenis: Article from Bulletin/Magazine Dalam koleksi: SCIENCE (keterangan: ada di Proquest) vol. 316 no. 5825 (May 2007), page 750. Topik: Biomedicine Ketersediaan Perpustakaan FK Nomor Panggil: S01.K.2007.05 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada     Lihat Detail Induk Isi artikel Many potential treatments for Alzheimer's disease target amyloid-B peptides (AB), which are widely presumed to cause the disease. The microtubule-associated protein tau is also involved in the disease, but it is unclear whether treatments aimed at tau could block AB-induced cognitive impairments. Here, we found that reducing endogenous tau levels prevented behavioral deficits in transgenic mice expressing human amyloid precursor protein, without altering their high AB levels. Tau reduction also protected both transgenic and nontransgenic mice against excitotoxicity. Thus, tau reduction can block AB- and excitotoxin-induced neuronal dysfunction and may represent an effective strategy for treating Alzheimer's disease and related conditions. Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Kembali

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