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Blastocyst Axis Is Specified Independently of Early Cell Lineage But Aligns with the ZP Shape
Oleh:
Kurotaki, Yoko
;
Hatta, Kohei
;
Nakao, Kazuki
;
Nabeshima, Yo-ichi
;
Fujimori, Toshihiko
Jenis:
Article from Bulletin/Magazine
Dalam koleksi:
SCIENCE (keterangan: ada di Proquest) vol. 316 no. 5825 (May 2007)
,
page 719.
Topik:
Biology
Ketersediaan
Perpustakaan FK
Nomor Panggil:
S01.K.2007.05
Non-tandon:
1 (dapat dipinjam: 0)
Tandon:
tidak ada
Lihat Detail Induk
Isi artikel
The mechanisms controlling the establishment of the embryonic-abembryonic (E-Ab) axis of the mammalian blastocyst are controversial. We used in vitro time-lapse imaging and in vivo lineage labeling to provide evidence that the E-Ab axis of the mouse blastocyst is generated independently of early cell lineage. Rather, both the boundary between two-cell blastomeres and the E-Ab axis of the blastocyst align relative to the ellipsoidal shape of the zona pellucida (ZP), an extraembryonic structure. lack of correlation between cell lineage and the E-Ab axis can be explained by the rotation of the embryo within the ZP.
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