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ArtikelBlastocyst Axis Is Specified Independently of Early Cell Lineage But Aligns with the ZP Shape  
Oleh: Kurotaki, Yoko ; Hatta, Kohei ; Nakao, Kazuki ; Nabeshima, Yo-ichi ; Fujimori, Toshihiko
Jenis: Article from Bulletin/Magazine
Dalam koleksi: SCIENCE (keterangan: ada di Proquest) vol. 316 no. 5825 (May 2007), page 719.
Topik: Biology
Ketersediaan
  • Perpustakaan FK
    • Nomor Panggil: S01.K.2007.05
    • Non-tandon: 1 (dapat dipinjam: 0)
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Isi artikelThe mechanisms controlling the establishment of the embryonic-abembryonic (E-Ab) axis of the mammalian blastocyst are controversial. We used in vitro time-lapse imaging and in vivo lineage labeling to provide evidence that the E-Ab axis of the mouse blastocyst is generated independently of early cell lineage. Rather, both the boundary between two-cell blastomeres and the E-Ab axis of the blastocyst align relative to the ellipsoidal shape of the zona pellucida (ZP), an extraembryonic structure. lack of correlation between cell lineage and the E-Ab axis can be explained by the rotation of the embryo within the ZP.
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