Detail The After-Hours Mutant Reveals a Role for Fbxl3 in Determining Mammalian Circadian Period   Oleh:  Godinho, Sofia I.H. ; Maywood, Elizabeth S. ; Shaw, Linda ; Tucci, Valter ; Barnard, Alun R. ; Busino, Luca ; pagano, Michele ; Kendall, Rachel ; Quwailid, Mohamed M. ; Romero, M. Rosario ; O'neill, John ; Chesham, Johanna E. ; Brooker, Debra ; Lalanne, Zuzanna ; Hastings, Michael H. ; Nolan, Patrick M. Jenis: Article from Bulletin/Magazine Dalam koleksi: SCIENCE (keterangan: ada di Proquest) vol. 316 no. 5826 (May 2007), page 894. Ketersediaan Perpustakaan FK Nomor Panggil: S01.K.2007.05 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada     Lihat Detail Induk Isi artikel By screening N-ethyl-N-nitrosourea-mutagenized animals for alterations in rhythms of wheel¬running activity, we identified a mouse mutation, after hours (Afh). The mutation, a Cys358Ser substitution in Fbxl3, an F-box protein with leucine-rich repeats, results in long free-running rhythms of about 27 hours in homozygotes. Circadian transcriptional and translational oscillations are attenuated in Afh mice. The Afh allele significantly affected Per2 expression and delayed the rate of Cry protein degradation in Per2::Luciferase tissue slices. Our in vivo and in vitro studies reveal a central role for Fbxl3 in mammalian circadian timekeeping. Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Kembali

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