Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences  

Oleh:

Mikkelsen, Tarjei S. ; Wakefield, Matthew J ; Aken, Bronwen ; Amemiya, Chris T ; Chang, Jean L. ; Duke, Shannon ; Garber, Manuel ; Gentles, Andrew J. ; Goodstadt, Leo ; Heger, Andreas ; Jurka, Jerzy ; Kamall, Michael ; Mauceli, Evan ; Searle, Stephen M.J. ; Sharpe, Ted ; Baker, Michelle L ; Batzer, Mark A ; Benos, Panayiotis V ; Belov, Katherine ; Clamp, Michele ; Cook, April ; Cuff, James ; Das, Radhika ; Davidow, Lance ; Deakin, Janine E ; Fazzari, Melissa J. ; Glass, Jacob L. ; Grabherr, Manfred ; Greally, John M. ; Gu, Wanjun ; Hore, Timothy A ; Huttle, Gavin A ; Kleber, Michael ; Jirtle, Randy L ; Koina, Edda ; Lee, Jeannie T. ; Mahony, Shaun ; Marra, Marco A. ; Milier, Robert D. ; Nicholls, Robert D. ; Oda, Mayumi ; Papenfuss, Anthony T. ; Parra, Zuly E. ; Pollock, David D. ; Ray, David A. ; Schein, Jacqueline E. ; Speed, Terence P ; Thompson, Katherine ; VandeBerg, John L. ; Wade, Claire M. ; Walker, Jerilyn A. ; Waters, Paul D. ; Webber, Caleb ; Weidman, Jennifer R. ; Xie, Xiaohui ; Zody, Michael C. ; Broad Institute Genome Sequencing Platform ; Broad Institute Whole Genome Assembly Team ; Graves, Jennifer A. Marshall ; Ponting, Chris P. ; Breen, Matthew ; Samollow, Paul B. ; Lander, Eric S ; Lindblad-Toh, Kerstin

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: NATURE (keterangan: ada di Proquest) vol. 447 no. 7141 (May 2007), page 167.

Ketersediaan

Perpustakaan FK Nomor Panggil: N01.K.2007.05 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

We report a high-quality draft of the genome sequence of the grey, short-tailed opossum (Monodelphis domestica). As the first metatherian ('marsupial')species to be sequenced, the opossum provides a unique perspective on the organization and evolution of mammalian genomes. Distinctive features of the opposum chromosomes provide support to recent theories about genome evolution and function, including a strong influences of biased gene conversion on nucleotide sequences composition, and a relationship between chromosomal characteristics and X chromosome inactivation. Comparison of non-coding functional elements opossum and eutherian genomes also reveals a sharp differenceto be relatively rare, with lineage-specific differences being largely due to diversification and rapid turnover in gene turnover in gene families involved in environmental interactions. In contrast, about 20% of eutherian conserved non-coding elements (CNEs) are recent inventions that postdate the divergence of Eutheria and Metatheria. A substansial proportion of these eutherian-specific CNEs arose from sequence inserted by transposons as a major creative force in the evalution of mammalian gene regulation.

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