Detail The Role of Traditional Medicine in the Treatment of Multidrug-resistant Pulmonary Tuberculosis, Myanmar   Oleh:  Soe, Paing ; Lwin, Than ; Chit, Khin ; Zin, Thaw ; Ti, Ti Jenis: Article from Bulletin/Magazine Dalam koleksi: Regional Health Forum vol. 10 no. 02 (2006), page 1. Ketersediaan Perpustakaan FK Nomor Panggil: R01.K.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada     Lihat Detail Induk Isi artikel Extracts of reputed medicinal plants used in Myanmar for treatment of suppurative lung disease were screened for in vitro activity on Mycobacterium tuberculosis (H37 RV strain). Plants showing satisfactory efficacy were further subjected to phyto-chemical characterization and acute and sub-acute toxicity testing before having approval from the National Ethical Committee, Department of Medical Research (Lower Myanmar). Five out of 11 medicinal plant extracts, coded as PTBOO2, PTBOO3, PTBOO5, PTBOO7 and PTBOO9, were found to possess significant in vitro anti-mycobacterial activity. Chemical screening did not indicate any presence of toxic organic constituents. Acute and sub-acute toxicity tests in mice and rats showed no significant abnormalities in biochemical, haematological and histopathological changes in both the control and the test groups. With due consideration to medical ethics in human trials, the above-mentioned five promising plant extracts were allowed for clinical trials, on selected culture-proven multidrug-resistant tuberculosis (MDR-TB) patients from the Aung San Tuberculosis Hospital who had not shown satisfactory response to the routinely-administered second-line anti-TB drugs up to a minimum of two years. Also, for ethical reasons, the plant extracts were only allowed to be given in addition to the second-line anti-TB drugs already being administered (kanamycin, thiacetazone or quinolones), to which the patients had shown no response. A dose-finding study was conducted, starting from the minimal dose used by traditional practitioners, and slowly increasing it to its maximum tolerable level. All plant extracts were found to be well tolerated and all patients showed significant improvement after three to 12 months of treatment. This study indicated that the reputed indigenous medicinal plants of Myanmar can become potentially valuable anti-TB drugs in the future. Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Kembali

Copyright © 2006, 2007 Unika Atma Jaya, all rights reserved