Rapid diagnostic tests compared with malaria microscopy for guiding outpatient treatment of febrile illness in Tanzania: randomised trial  

Oleh:

Reyburn, Hugh ; Mbakilwa, Hilda ; Mwangi, Rose ; Mwerinde, Mbeni ; Drakeley, Chris ; Whitty, Christopher J.M.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: British Medical Journal (keterangan: ada di Proquest) vol. 334 no. 7590 (Feb. 2007), page 403.

Ketersediaan

Perpustakaan FK Nomor Panggil: B16.K.2007.04 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective To compare rapid diagnostic tests (RDTs) for malaria with routine microscopy in guiding treatment decisions for febrile patients. Design Randomised trial. Setting Outpatient departments in northeast Tanzania at varying levels of malaria transmission. Participants 2416 patients forwhom a malaria test was requested. Intervention Staffreceived training on rapid diagnostic tests; patients sent for malaria tests were randomised to rapid diagnostic test or routine microscopy. Main outcome measure Proportion of patients with a negative test prescribed an antimalarial drug. Results Of7589 outpatient consultations, 2425 (32%) had a malaria test requested. Of 1204 patients randomised to microscopy, 1030 (86%) tested negative for malaria; 523 (51 %) of these were treated with an antimalarial drug. Of 1193 patients randomised to rapid diagnostic test, 1005 (84%) tested negative; 540 (54%) of these were treated for malaria (odds ratio loB, 95% confidence interval 0.95 to 1.34; P=0.18). Children aged under 5 with negative rapid diagnostic tests were more likely to be prescribed an antimalarial drug than were those with negative slides (P=0.003). Patients with a negative test by any method were more likely to be prescribed an antibiotic (odds ratio 6.42, 4.72 to 8.75; P

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