Is migraine with aura associated with increased risk of cardiovascular disease?  

Oleh:

Launer, Lenora J.

Jenis: Article from Bulletin/Magazine - ilmiah internasional
Dalam koleksi: Medical Progress vol. 34 no. 05 (May 2007), page 214.

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Perpustakaan FK Nomor Panggil: M36.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Original article: Kurth T, et al. Migraine and risk of cardiovascular disease in women. JAMA 2006;296:283-291. 8ACKGROUND: To examine the association between migraine with or without aura and the risk of cardiovascular disease (CVD). DESIGN: During 1992-1995, 27,840 women aged 45 years or older who had no history of CVD were enrolled into the Women's Health Study, a prospective cohort study conducted in the US. At baseline, 5,125 women reported a history of migraine, with 1,515 women reporting a past history of migraine, but no migraine attack during the past year, and 3,610 women reporting active migraine (defined as migraine in the year before baseline; 1.434 women had active migraine with aura [MAl and 2,176 women had active migraine without aura [MOJ). The mean follow-up time was 10 years. Cox proportional hazards models were used to examine the association between migraine status and various outcome measures. RESULTS: During follow-up, 580 major CVD events were observed. The incidence rates of all outcome events were higher in women with self-reported active MA than!n women who had no history of migraine or in those who had active MO. Women with a past history of migraine had increased incidence rates for coronary revascularization and angina. After adjustment for multiple variables, and compared with women who had never had migraine, women with active MA had hazard ratios of 2.15 for major CVD (95% Cl1.58-2.92; P <0.001),1.91 for ischaemic stroke (95% Cl1.17-3.10; P = 0.01). 2.08 for MI (95% CI1.30-3.31; P = 0.002),1.74 for coronary revascularization (95% CI1.23-2.46; P = 0.002), 1.71 for angina (95% ClI.16-2.53; P = 0.007) and 2.33 for ischaemic CVD death (95% Cl1.21-4.51; P = 0.01). By contrast, women with active MO did not have significantly increased risks for any of the outcome measures. Women with a past history of migraine had increased risks for coronary revascularization (hazard ratio 1.46, 95% CI 1.07-2.00; P = 0.02) and angina (hazard ratio 1.66,95% CI1.19-2.32; P = 0.003). CONCLUSION: MA was associated with an increased risk of vascular events and angina, but MO was not.

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