Dietary -linolenic acid inhibits proinflammatory cytokine production by peripheral blood mononuclear cells in hypercholesterolemic subjects  

Oleh:

Zhao, Guixiang ; Etherton, Terry D. ; Martin, Keith R. ; Gillies, Peter J. ; West, Sheila G. ; Kris-Etherton, Penny M

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The American Journal of Clinical Nutrition vol. 85 no. 02 (Feb. 2007), page 385.

Ketersediaan

Perpustakaan FK Nomor Panggil: A07.K.2007.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Background:Atherosclerosis is a chronic inflammatory disease. We previously reported that a diet high in -linolenic acid (ALA) reduces lipid and inflammatory cardiovascular disease risk factors in hypercholesterolemic subjects. Objective:The objective was to evaluate the effects of a diet high in ALA on serum proinflammatory cytokine concentrations and cytokine production by cultured peripheral blood mononuclear cells (PBMCs) from subjects fed the experimental diets. Design:A randomized, controlled, 3-diet, 3-period crossover study design was used. Hypercholesterolemic subjects (n = 23) were assigned to 3 experimental diets: a diet high in ALA (ALA diet; 6.5% of energy), a diet high in linoleic acid (LA diet; 12.6% of energy), and an average American diet (AAD) for 6 wk. Serum interleukin (IL)-6, IL-1ß, and tumor necrosis factor- (TNF-) concentrations and the production of IL-6, IL-1ß, and TNF- by PBMCs were measured. Results:IL-6, IL-1ß, and TNF- production by PBMCs and serum TNF- concentrations were lower (P < 0.05 and P < 0.08, respectively) with the ALA diet than with the LA diet or AAD. PBMC production of TNF- was inversely correlated with ALA (r = –0.402, P = 0.07) and with eicosapentaenoic acid (r = –0.476, P = 0.03) concentrations in PBMC lipids with the ALA diet. Changes in serum ALA were inversely correlated with changes in TNF- produced by PBMCs (r = –0.423, P < 0.05). Conclusions:Increased intakes of dietary ALA elicit antiinflammatory effects by inhibiting IL-6, IL-1ß, and TNF- production in cultured PBMCs. Changes in PBMC ALA and eicosapentaenoic acid (derived from dietary ALA) are associated with beneficial changes in TNF- release. Thus, the cardioprotective effects of ALA are mediated in part by a reduction in the production of inflammatory cytokines.

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