Comparative Study to Find the Relationship of Plasma Homocysteine Levels in Patients of Mild and Severe Preeclampsia  

Oleh:

Amir, Sadia ; Ahmad, M. Zamir ; Ul-Ain, Qurrat ; Shamsi, Adina ; Sultana, Kaukab

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: SGH Medical Journal vol. 1 no. 2 (Jul. 2006), page 118.
Topik: hyperhomocysteinemia; primigravida; mild preeclampsia; severe preeclampsia; third trimester of pregnancy.

Ketersediaan

Perpustakaan FK Nomor Panggil: S09.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Preeclampsia is pregnancy induced hypertension which classically includes a triad of clinical signs and symptoms – hypertension, proteinuria and pathologic edema. Its exact etiology is uncertain. There are many chronic, exogenous and pregnancy associated risk factors. The aim of this study was to determine the plasma homocysteine level in patients of preeclampsia and normal pregnant females and to compare the fasting plasma homocysteine level in patients of mild preeclampsia and severe preeclampsia as hyperhomocysteinemia is one of the important chronic risk factor for preeclampsia. Sixty preeclamptic primigravida in third trimester of pregnancy were included in this study, consisting of thirty with mild preeclampsia and thirty with severe preeclampsia. Thirty primigravida (30-38 weeks of gestation) with normal pregnancy were taken as control group. Fasting plasma homocysteine level was estimated in all the three groups. The study showed that plasma homocysteine level was high significantly in preeclamptic patients than control subjects, but it was not statistically different between mild preeclampsia group and severe preeclampsia group. This showed that raised plasma homocysteine level although playing a role in causation of preeclampsia, yet it does not play a role in the severity of preeclampsia.

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