Prognostic Value of Cell Cycle and Apoptosis Regulatory Proteins in Mismatch Repair-Proficient Colorectal Cancer: A Tissue Microarray-Based Approach  

Oleh:

Tornillo, Luigi ; Lugli, Alessandro ; Zlobec, Inti ; Willi, Niels ; Glatz, Kathrin ; Lehmann, Frank ; Spichtin, Hans-Peter ; Maurer, Robert ; Stoios, Dimitra ; Sauter, Guido ; Terracciano, Luigi

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: American journal of Clinical Pathology vol. 127 no. 1 (Jan. 2007), page 114 - 123 .
Topik: Cell cycle proteins; Apoptosis regulator proteins; Colorectal cancer; Tissue microarray; Immunohistochemistry

Ketersediaan

Perpustakaan FK Nomor Panggil: A08.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Cell cycle and apoptosis regulatory proteins are markers of tumor progression in colorectal cancer. In a series of 1,274 mismatch repair-proficient colorectal cancers, immunohistochemical analysis of p21, p27, p53, and bcl-2 expression was performed using the tissue microarray technique. In univariate analysis, p21 expression was associated with tumor location and pN0; p27 expression with tumor location, lower tumor grade, early pT, and pN; p53 expression with tumor location; and bcl-2 with early pT and pN. Expression of p27 identified subgroups with worse prognosis in pT3 N0 and pT3 N+ patients. None of the 4 tumor markers were independent prognostic indicators of survival. The multimarker phenotypes p21/p27/p53 and p21/p27/bcl-2 were associated with survival. In mismatch repair-proficient colorectal cancer, p27 expression is associated with a better prognosis, and pT, pN, and vascular invasion are independent prognostic factors. In addition, multimarker phenotypes are useful to identify colorectal cancer subgroups with different prognoses.

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