Hemolysis in Double-Filtration Plasmapheresis  

Oleh:

Yeh, Jiann-Horng

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: American journal of Clinical Pathology vol. 127 no. 1 (Jan. 2007), page 76 - 80.
Topik: Double-filtration plasmapheresis; Hemolysis; Transmembrane pressure; Vascular access; Heparin

Ketersediaan

Perpustakaan FK Nomor Panggil: A08.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

To evaluate the occurrence of hemolysis during double-filtration plasmapheresis (DFP) treatment and its causes, we prospectively treated 113 myasthenic patients and monitored transmembrane pressure (TMP), arterial line pressure (Pa), and venous line pressure (Pv) at 30-minute intervals (M30, M60, M90, and M120) during treatment. Laboratory and clinical parameters related to the development of hemolysis were also analyzed. The overall frequency of hemolysis was 35.4%. Peripheral venous access was associated with a higher rate of hemolysis (45.3%) The mean TMP increased significantly after M30 for the hemolysis group compared with the no hemolysis group. A similar trend was present for Pa. Pv did not differ between the 2 groups during treatments until M90 and M120. Pa and TMP changed significantly with time (both P < .0001). Vascular access through large veins and stable TMP during the procedure may help avoid hemolysis.

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