Profil Disolusi Berbagai Macam Tablet Fenilbutazon yang Beredar Di Pasaran  

Oleh:

Athijah, Umi ; Suprapti, Budi ; Yulistiani ; Zulkarnain, Bambang Subakti

Jenis: Article from Journal - ilmiah nasional
Dalam koleksi: Jurnal Penelitian Medika Eksakta vol. 03 no. 02 (Aug. 2002), page 130-137.
Topik: Phenylbutazone; dissolution profile
Fulltext: Umi Athijah.pdf (117.34KB)

Ketersediaan

Perpustakaan PKPM Nomor Panggil: J101 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

The objective of this study was to identify the dissolution profile of various phenylbutazone tablets in market using content homogeneity and dissolution efficiency as a parameters. Four phenylbutazone tablets labeled as A, B, C and D were used in this study. The homogeneity test was carried out using methanol as a medium. A basket method of USP XXIII using buffer phosphate pH 7.5 was applied as a dissolution test procedure. The content homogeneity test resulted in that A, B and D met the standard requirement whereas C had the content homogeneity exceed that requirement. Furthermore, the dissolution test results showed that A and D did not meet the standard requirement of USP XXIII. In contrast, B and C met that standard requirement. Also, 60 minutes dissolution efficiency (ED60) showed there were significantly different among them (ANOVA and Tuckey HSD a = 0.05). In conclusion, the content homogeneity and dissolution efficiency of four phenylbutazone tablets showed that there were different in quality. The results of this study should be informed to the relevant institution and pharmaceutical industries to improve the product quality.

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