PENGARUH BERBAGAI DOSIS CITRININ TERHADAP KERUSAKAN STRUKTUR HEPATOSIT MENCIT (Mus musculus) PADA TIGA ZONA LOBULUS HEPAR. THE EFFECT OF SEVERAL DOSES OF CITRININ TO THE HEPATOCYTE STRUCTURE DAMAGE OF MICE (Mus musculus) ON THREE HEPAR LOBULUS ZONE  

Oleh:

Hastuti, Utami Sri

Jenis: Article from Journal - ilmiah nasional
Dalam koleksi: Jurnal Kedokteran Brawijaya vol. 22 no. 03 (Dec. 2006), page 121-126.
Topik: Citrinin Dose; Hepatocyte Structure Damage; Hepar Lobulus Zone

Ketersediaan

Perpustakaan FK Nomor Panggil: J34.K.2004-2006.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Citrinin is a sort of mycotoxin which caused mycotoxicosis. Citrinin is produced by Penicillium citrinum mold that can contaminate sort of food especially damaged beans. Citrinin is known as nephrotoxic as well as hepatotoxic mycotoxin and caused hepatocite structure damage. This research was done: 1) to know the effect of citrinin to hepatocite structure damage; 2) to know the effect of citrinin dose difference to the value of the hepatocyte structure damage; 3) to know the effect of cit rinin to the value of hepatocyte structure damage on three zones of heparlobulus. The samples of this research were male mice (Mus musculus) var. BALB-C at the age of three months. The experiment group of mice was orally administered with citrinin in three doses, i.e: dose-I: 1 mg/kg BW; dose-2: 1,75 mg/kg BW; dose-3: 2,5 mgI kg BW. Hepatocyte structure damage is observed on centrilobular zone, midzone, and perifer zone. The hepatocyte structure damage examination is done by histopathologycal and ultra structural examination by electron microscope. The research results showed that: 1) there was an effect of citrinin to hepatocyte structure damaged cellular as well as sub cellular; 2) there was a difference effect of some dose of citrinin on the value of hepatocyte structure damaged by cellular; 3) dose-3 (2,5 mg/kg BW) was the highest dose which cause hepatocyte damage on three zones of hepar lobulus; 4) citrinin effect was different for on hepatocyte, on three zones of heparlobulus; 5) the perifer zone was the highest damaged area of three hepar lobulus zones.

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