Dietary fatty acid intakes and the risk of ovulatory infertility  

Oleh:

Chavarro, Jorge E. ; Rich-Edwards, Janet W. ; Rosner, Bernard A. ; Willett, Walter C.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The American Journal of Clinical Nutrition vol. 85 no. 01 (Jan. 2007), page 231.
Topik: Diet • dietary fatty acids • infertility • ovulation • reproductive medicine • nutritional epidemiology

Ketersediaan

Perpustakaan FK Nomor Panggil: A07.K.2007.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

1 From the Departments of Nutrition (JEC and WCW), Epidemiology (JEC, JWR-E, and WCW), and Biostatistics (BAR), Harvard School of Public Health, Boston, MA; and the Department of Ambulatory Care and Prevention (JWR-E) and the Channing Laboratory, Department of Medicine, Brigham and Women's Hospital (JWR-E, BAR, and WCW), Harvard Medical School, Boston, MA. Background:Pharmacologic activation of the peroxisome proliferator–activated receptor (PPAR-) improves ovulatory function in women with polycystic ovary syndrome, and specific dietary fatty acids can affect PPAR- activity. Objective:The objective of the study was to assess whether the intakes of total fat, cholesterol, and major types of fatty acids affect the risk of ovulatory infertility. Design:We conducted a prospective cohort study of 18 555 married, premenopausal women without a history of infertility who attempted a pregnancy or became pregnant between 1991 and 1999. Diet was assessed twice during follow-up by using a food-frequency questionnaire. Results:During follow-up, 438 incidents of ovulatory infertility were reported. In logistic regression analyses, intakes of total fat, cholesterol, and most types of fatty acids were not related to ovulatory infertility. Each 2% increase in the intake of energy from trans unsaturated fats, as opposed to that from carbohydrates, was associated with a 73% greater risk of ovulatory infertility after adjustment for known and suspected risk factors for this condition [relative risk (RR) = 1.73; 95% CI: 1.09, 2.73]. Obtaining 2% of energy intake from trans fats rather than from n–6 polyunsaturated fats was associated with a similar increase in the risk of ovulatory infertility (RR = 1.79; 95% CI: 1.11, 2.89). In addition, obtaining 2% of energy from trans fats rather than from monounsaturated fats was associated with a more than doubled risk of ovulatory infertility (RR = 2.31; 95% CI: 1.09, 4.87). Conclusion:trans Unsaturated fats may increase the risk of ovulatory infertility when consumed instead of carbohydrates or unsaturated fats commonly found in nonhydrogenated vegetable oils.

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