Analisis Mikrodelesi Kromosom Y pada Pria Azoospermia di Indonesia  

Oleh:

Moeloek, Nukman ; Citrawati, Mila ; Sari, Puji ; Yurnadi ; Suryandari, Dwi Anita

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Makara Seri Kesehatan vol. 10 no. 1 (2006), page 41-46.
Topik: Y-chromosome; Azoospermia; Microdeletion

Ketersediaan

Perpustakaan Pusat (Semanggi) Nomor Panggil: MM75.1 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Analysis of Y Chromosome Microdeletion in Indonesian Males. The aim of this study is to fmd out Y chromosome microdeletion in Indonesian azoospermic men. This study used the PCR method with five STS to locate deletion on three different subregions (AZFa, AZPb, and AZFc) of azoospermic. men and one STS to amplify SRY gen which act as an internal control. In this study we detected two of 35 (5,7%) azoospermic men had microdeletion Yq. One had microdeletion on subregion AZFa (sY84) and AZFb (RBMY1) and the other one on subregion AZFc (sY254 and sY255). Therefore microdeletion of the Y chromosome in Indonesian azoospermic men excist. Examination of microdeletion of Y chromosomes in azoospermic men is important if they are going to participate in the Intra Cytoplasmic Infection Program to avoid genetic disorders of theirdhscendants.

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