Reactions of Cisplatin Hydrolytes With Thiols. 3: Reactions of cis-[Pt(15nh3)2(H2o)2]2+ With Glutathione  

Oleh:

Hadi, Sutopo

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Makara Seri Sains vol. 10 no. 1 (2006), page 19-23.
Topik: 15N NMR; Glutathione; Cisplatin Hydrolytes

Ketersediaan

Perpustakaan Pusat (Semanggi) Nomor Panggil: MM65.2 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

The reaction of cis-[Pt(’5NH3)2(H2O)2]2’~ (3) with glutathione (GSH) was investigated in aqueous solution. In this reaction, the ammine in the platinum complex formed was liberated. Surprisingly two chelate rings were observed, six¬membered-S,O-chelate ring complex cis-[Pt(~NH3)2(SG-S,O) (7) and five-membered-S,N-chelate ring complex cis¬[Pt(’5NH3)2(SG-S,N)] (8). The bis (thiolate) platinum(II) complex, cis-[Pt(’5NH3)2(SG)2] (9) was always present in this reaction in any mole ratio used. The dinuclear sulphur-bridged complex (10), giving a broad peak in ‘N NMR, was only present in very tiny amounts.

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