Quinolones Sensitize Gram-Negative Bacteria to Antimicrobial Peptides  

Oleh:

[s.n]

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Antimicrobial Agents and Chemotherapy vol. 50 no. 07 (Jul. 2006), page 2361.
Topik: Quinolones; Antimicrobial Peptides

Ketersediaan

Perpustakaan FK Nomor Panggil: A21.K, A21.K.2006.03 Non-tandon: 3 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

The treatment of infection caused by bacteria resistant to the vast majority of antibiotics is a challenge worldwide. Antimicrobial peptides (APs) make up the front line of defense in those areas exposed to microorganism, and there is intensive research to explore their use as new antibacterial agents. On the other hand, it is known that subinhibitory concentrations of antibiotics affect the expression of numerous bacterial traits. In this work we evaluated whether treatment of bacteria with subinhibitory concentrations of quinolones may alter the sensitivity to APs. Incubation with ciprofloxacin did not alter the expression of the K. Pneumoniae loci involved in resistance to APs. A 1-N-phenyl-naphthylamine assay showed that ciprofloxacin and levofloxacin increased the permeabilities of the K. Pneumoniae and P. aeruginosa outer membranes, while divalent cations antagonized this action. Finally, we demonstrated that ciprofloxacin and levofloxacin increased the binding of APs to the outer membrane by using dansylated polymyxin B.

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