Activity of LBM415 Compared to those of 11 Other Agents against Haemophilus Species  

Oleh:

[s.n]

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Antimicrobial Agents and Chemotherapy vol. 50 no. 07 (Jul. 2006), page 2323.
Topik: Activity of LBM415 Haemophilus Species

Ketersediaan

Perpustakaan FK Nomor Panggil: A21.K, A21.K.2006.03 Non-tandon: 3 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

When tested against 254 Haemophilus influenzae strains, LBM415, a peptide deformylase inhibitor, gave MIC50 and MIC90 values of 2.0 ug/ml and 8.0 ug/ml, respectively. The MICs were independent of B-Lactam or quinolone susceptibility and the presence or absence of macrolide efflux or ribosomal protein mutations. The MICs of LBM415 against 23 H.parainfluenzae strains were similar to those against H. influenzae. In contrast, erythromycin, azithromycin, and clarithomycin gave unimodal MIC distributions, and appart from B-Lactamase-Negative, ampicilin-resistant strains, all strains were susceptible to the B-Lactam tested. Apart from selected quinolone-resistant strains, all strains were susceptibele to ciprofloxacin, levofloxacin, gatifloxacin, moxifloxacin, and gemifloxacin. Resistance to trimethoprim-sulfamethoxazole was common. The potencies of all drugs against 23 H. parainfluenzae strains were similar to those against H. influenzae. Time-kill studies with 10 Haemophilus strains showed LBM415 to be bactericidal at 2x the MIC against 8 of 10 strains after 24 h. For comparison, the macrolides and B-Lactam were bactericidal against 8 to 10 strains each at 2x the MIC after 24 h. Quinolones were bactericidal against all 10 strains tested at 2x the MIC after 24 h. Against six H. influenzae strains, postantibiotic effects for LBM415 lasted between 0.8 and 2.2 h. In multistep resistance selection studies, LBM$!% produced resistant clones in 7 of the 10 strains tested, with MICs ranging from 4 to 64 ug/ml. No mutation in deformylase (def) and formyltransferase (fmt) genes were detected in any of he LBM415-resistant mutants.

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali