Multiple cis-Acting Sequences Mediate Upregulation of the MDRI Efflux Pump in a Fluconazole-Resistant Clinical Candida Albicans Isolate  

Oleh:

[s.n]

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Antimicrobial Agents and Chemotherapy vol. 50 no. 07 (Jul. 2006), page 2300.
Topik: Fluconazole-Resistant Candida Albicans

Ketersediaan

Perpustakaan FK Nomor Panggil: A21.K, A21.K.2006.03 Non-tandon: 3 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Overexpression of the MDRI gene, which encodes a multidrug efflux pump of the major facilitator superfamily, is a frequent cause of resistance to the antimycotic agent fluconazole and other metabolic inhibitor in clinical Candida albicans strains. The multiple transcription factors control expression of the MDRI efflux pump in C. albicans and that the mutation(s) that causes constitutive MDRI overexpression and drug resistance in clinical C. albicans isolates affects the activities of several of these transcription factors.

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