| Purpose. To provide an overview of select existing fatigue models and propose a neuroendocrine-based regulatory fatigue model that can serve as a foundation for interventions to manage fatigue. Conceptual Framework. Biobehavioral systems based on a neuroendocrine regulatory framework. Methods. Empirical data and literature review to develop a fatigue model to serve as a foundation for interventions to manage fatigue. Conclusions. The proposed model will facilitate testing of interventions based on the premise that common neuroendocrine transmitters provide the mechanisms of fatigue in patients diagnosed with chronic illnesses, such as with cancer treatment?related fatigue. The model may also be used to identify predictors of fatigue in specific patient populations, provide guidance for clinicians in their selection of precise interventions to be implemented, and identify the effects of treatments captured in these populations. By clearly identifying the mechanisms of fatigue,we can discover which interventions are effective for particular types of fatigue. |