Detail The Effects of Non?Weight Bearing on Skeletal Muscle in Older Rats: An Interrupted Bout versus an Uninterrupted Bout Bibliografi Author: Gehrke P.T., Alissa Guildner ; Krull P.T., Margaret Sheie (Co-Author); McDonald P.T., Robin Shotwell (Co-Author); Thoele P.T., Jessica (Co-Author); Sparby P.T., Tracy (Co-Author) Topik: non?weight bearing; single-fiber crosssectional area; soleus; bed rest; hind limb unweighting; extensor digitorum longus Bahasa: (EN )     Penerbit: SAGE Publications     Tempat Terbit: London    Tahun Terbit: 2004     Jenis: Article - untuk jurnal ilmiah Fulltext: 195BRN53.pdf (75.0KB; 0 download) Abstract Age-related changes in skeletal muscle, in combination with bed rest, may result in a poorer rehabilitation potential for an elderly patient. The purpose of this study was to determine the effects of non-weight bearing (hind limb unweighting [HU])on the soleus and extensor digitorum longus (EDL)in older rats. Two non-weight bearing conditions were used: an uninterrupted bout of HU and in interrupted bout of HU. Twenty-one rats were randomly placed into 1 of 3 groups: control, interrupted HU (2 phases of 7 days of HU, separated by a 4-day weight-bearing phase)and an uninterrupted HU (18 uninterrupted days of HU). Following non-weight bearing, the soleus and EDL muscles were removed. Fiber type identification was performed by myofibrillar ATPase and cross-sectional area was determined. The findings suggest that any period of non-weight bearing leads to a decrease in muscle wet weight (19%-45%). Both type I and type II fibers of the soleus showed atrophy (decrease in crosssectional area, 35%-44%)with an uninterrupted bout of non-weight bearing. Only the type II fibers of the soleus showed recovery with an interrupted bout of weight bearing. In the EDL, type II fibers were more affected by an uninterrupted bout of non-weight bearing (15% decrease in fiber size)compar ed to the type I fibers. EDL type II fibers showed more atrophy with interrupted bouts of non-weight bearing than with a single bout (a 40% compared to a 15% decrease). This study shows that initial weight bearing after an episode of non-weight bearing may be damaging to type II fibers of the EDL. Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Lihat Sejarah Pengadaan  Konversi Metadata   Kembali

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