Tolerance: Is it Achievable in pediatric Solid Organ Transplantation?  

Oleh:

Pearl, Jonathan P. ; Preston, Edwin ; Kirk, Allan D.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Pediatric Clinics of North America vol. 50 no. 06 (Dec. 2003), page 1261.

Ketersediaan

Perpustakaan FK Nomor Panggil: P13.K.2003.06 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Significant advances have been made in the understanding of allograft rejection. There is growing awareness that allograft acceptance, or tolerance, is also an active process rather than a passive absence of rejection. Mechanistic awareness of this process has spawned many preclinical strategies for the prevention of allograft rejection without the need for chronic immunosuppression. These therapies are currently entering clinical trials. This article reviews the prevailing therapies that hold promise for future clinical application. In particular, their application in children is discussed, as are biologic aspects of childhood immunity that may play a role in the success or failure of these strategies.

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