Mechanical Properties of A Biodegradable Bone Regeneration Scaffold  

Oleh:

Currier, B. L. ; Porter, B. D. ; Oldham, J. B. ; He, S.-L. ; Zobitz, Mark E. ; Payne, R. G. ; An, K. N. ; Mikos, A. G. ; Yaszemski, M. J.

Jenis: Article from Bulletin/Magazine
Dalam koleksi: Journal of Biomechanical Engineering vol. 122 no. 3 (2000), page 286-288.
Topik: Clock regeneration; mechanical properties; biodegradable bone; regeneration; scaffold

Ketersediaan

Perpustakaan Pusat (Semanggi) Nomor Panggil: JJ52.1 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Poly (Propylene Fumarate) (PPF), a novel, bulk erosion, biodegradable polymer, has been shown to have osteoconductive effects in vivo when used as a bone regeneration scaffold (Peter, S. J., Suggs, L. J., Yaszemski, M. J., Engel, P. S., and Mikos, A. J., 1999, J. Biomater. Sci. Polym. Ed., 10, pp. 363 – 373). The material properties of the polymer allow it to be injected into irregularly shaped voids in vivo and provide mechanical stability as well as function as a bone regeneration scaffold. We fabricated a series of biomaterial composites, comprised of varying quantities of PPF, NaCl and B - tricalcium phosphate (B - TCP), into the shape of right circular cylinders and tested the mechanical properties in four - point bending and compression. The mean modulus of elasticity in compression (E(c)) was 1204.2 MPa (SD 32.2) and the mean modulus of elasticity in bending (E(b)) was 1274.7 MPa (SD 125.7). All of the moduli were on the order of magnitude of trabecular bone. Changing the level of NaCl from 20 to 40 percent, by mass, did not decrease E(c) and E(b) significantly, but did decrease bending and compressive strength significantly. Increasing the B - TCP from 0.25 g/g PPF to 0.5 g/g PPF increased all of the measured mechanical properties of PPF / NVP composites. These results indicate that this biodegradable polymer composite is an attractive candidate for use as a replacement scaffold for trabecular bone.

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