Detail Use of Micropathways to Improve Oxygen Transport in A Hepatic System   Oleh:  Coger, Robin N. ; McClelland, Randall E. Jenis: Article from Bulletin/Magazine Dalam koleksi: Journal of Biomechanical Engineering vol. 122 no. 3 (2000), page 268-273. Topik: oxygen water; micropathways; oxygen transport; hepatic system Ketersediaan Perpustakaan Pusat (Semanggi) Nomor Panggil: JJ52.1 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada     Lihat Detail Induk Isi artikel Establishing suitable oxygen transport pathways within bioartificial liver replacement devices continues to be an important engineering challenge. Oxygen delivery is critical since this is one of the nutrients necessary to maintain hepatocyte viability and function. In the current study, the microporosity of a collagen extracellular matrix has been modified to permit both diffusion and convection mass transport. Using fluorescent visualization, the enhancement technique was found to extend the oxygen transport distance from 170 µm to 360 µm. Furthermore, in hepatocyte culture studies, the enhancement technique was observed to yield a sixfold increase in the amount of viable hepatocytes able to be sustained by a single O2 source. Normalized function studies confirm that hepatocyte function was also improved in the enhanced collagen configurations. Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Kembali

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