The Micromechanical Environment of Intervertebral Disc Cells : Effect of Matrix Anisotropy and Cell Geometry Predicted By A Linear Model  

Oleh:

Baer, Anthony E. ; Setton, Lori A.

Jenis: Article from Bulletin/Magazine
Dalam koleksi: Journal of Biomechanical Engineering vol. 122 no. 3 (2000), page 245-251.
Topik: GEOMETRY; micromechanical; environment; disc cells; matrix anisotropy; cell geometry; linear model

Ketersediaan

Perpustakaan Pusat (Semanggi) Nomor Panggil: JJ52.1 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Cells of the intervertebral disc exhibit spatial variations in phenotype and morphology that may be related to differences in their local mechanical environments. In this study, the stresses, strains, and dilatations in and around cells of the intervertebral disc were studied with an analytical model of the cell as a mechanical inclusion embedded in a transversely isotropic matrix. In response to tensile loading of the matrix, the local mechanical environment of the cell differed among the anatomic regions of the disc and was strongly influenced by changes in both matrix anisotropy and parameters of cell geometry. The results of this study suggest that the local cellular mechanical environment may play a role in determining both cell morphology in situ and the inhomogeneous response to mechanical loading observed in cells of the disc.

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali