A Novel Injectable Collagen Matrix : In Vitro Characterization and In Vivo Evaluation  

Oleh:

Rudnicki, Stewart ; Laude, Damien ; Odlum, Kevin ; Bachrach, Nathaniel

Jenis: Article from Bulletin/Magazine
Dalam koleksi: Journal of Biomechanical Engineering vol. 122 no. 3 (2000), page 231-235.
Topik: in vivo models; novel injectable; collagen matrix; in vitro characterization; in vivo evaluation

Ketersediaan

Perpustakaan Pusat (Semanggi) Nomor Panggil: JJ52.1 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

We present here a unique engineered collagen formulation that is injectable and compacts into a porous viscoelastic solid after implantation, achieving completely focal application without cross - linking. This implant provides a cohesive continuously porous matrix, as demonstrated by permeability and compression experiments. Those experiments also provide initial mechanical characterization of the material and establish the ability to modify these essential properties by design. Further, the short - term compaction and long - term stability of the implant in vivo in terms of both physical and histological responses are assessed in an animal model to demonstrate the mechanism of action and long - term persistence of this novel material.

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