Evaluation of The Effectiveness of Transurethral Radio Frequency Hyperthermia in The Canine Prostate : Temperature Distribution Analysis  

Oleh:

Xu, Lisa X. ; Zhu, Liang

Jenis: Article from Bulletin/Magazine
Dalam koleksi: Journal of Biomechanical Engineering vol. 121 no. 6 (1999), page 584-590.
Topik: distribution; effectiveness; transurethral radio; hyperthermia; canine prostate; temperature; distribution

Ketersediaan

Perpustakaan Pusat (Semanggi) Nomor Panggil: JJ52.1 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

The heating pattern of a transurethral radio frequency (RF) applicator and its induced steady - state temperature field in the prostate during transurethral hyperthermia treatment were investigated in this study. The specific absorption rate (SAR) of the electromagnetic energy was first quantified in a tissue - equivalent gel phantom. It was used in conjunction with the Pennes bioheat transfer equation to model the steady - state temperature field in prostate during the treatment. Theoretical predictions were compared to in vivo temperature measurements in the canine prostate and good agreement was found to validate the model. The prostatic tissue temperature rise and its relation to the effect of blood perfusion were analyzed. Blood perfusion is found to be an important factor for removal of heat especially at the higher RF heating level. To achieve a temperature above 44 °C within 10 percent of the prostatic tissue volume, the minimum RF power required ranges from 5.5 W to 36.4 W depending on the local blood perfusion rate (w = 0.2 - 1.5 ml/gm/min). The corresponding histological results from the treatment suggest that to obtain better treatment results, either higher RF power level or longer treatment time ( > 180 minutes) is necessary. This is consistent with the predictions from the theoretical model developed in this study.

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