Penyakit Creutzfeldt-Jakob Ditinjau dari Radiologi  

Oleh:

Uinarni, Herlina

Jenis: Article from Journal - ilmiah nasional - tidak terakreditasi DIKTI - atma jaya
Dalam koleksi: Majalah Kedokteran Damianus vol. 06 no. 01 (Jan. 2007), page 49-55.
Topik: technology; radiologic; Creutzfeldt-Jakob diseass; Diagnosis with other MR sequances; FLAIR
Fulltext: D01 v6 n1 p49 kelik2023.pdf (1,022.56KB)

Ketersediaan

Perpustakaan PKPM Nomor Panggil: M61 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada	Lihat Detail Induk
Perpustakaan FK Nomor Panggil: D01.K.2007.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada	Lihat Detail Induk

Isi artikel

Creutzfeldt-Jakob disease (CJD) is the most common human transmissible subacute spongiform encephalopathy (TSSE). Most CJD cases-approximately 85%-are sporadic. The remaining 15% consist of genetic forms (genetic CJD), gerstmann - straussler - scheinker disease, fatal familial insomnia) and iatrogenic forms transmitted by human growth hormone therapy, dura mater grafts and in a few instances, surgical procedure. A new variant of sporadic CJD (vCJD) is caused by the same agent as bovine spongiform encephalopahty (BSE). The cardinal manifestations of the disease are rapidly progressive dementia, generalized myoclonus, and periodic sharp wave complexes (PSWCs) on EEG. However, cases that do not consistently show such typical manifestations have been recognized and the spectrum of disease manifestations has been extending. An early and accurate diagnosis is important ot prevent the disease transmission but diagnosis is not easy, especially in the early stage of the disease. PSWCs on EEG have been used as one of the central diagnostic tests for CJD. HOwever PSWCs are observed in only 60% of patients and usually appear after the middle stage of the disease. In addition, PSWCs are not always specific for CJD. Recenty several reports described that diffusion weighted MRI (DWI) could demonstrate early brain lesions in CJD patients when scans were negative on T2 weighted MRI examination (T21), DWI for the early clinical diagnosis of CJD by comparing it with other MR sequences such as T21 and fluid attenuated inversion recovery imaging (FLAIR) and with other diagnostic tests including PSWC, CSF 14-3-3 protein, and CSF NSE, which are used as the world health organization (WHO) CJD diagnostic criteria.

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