Reactive Oxygen Species Cerebral Autoregulation in Health and Disease  

Oleh:

Terashvili, Maia ; Pratt, Phillip F. ; Gebremedhin, Debebe ; Narayanan, Jayashree ; Harder, David R.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Pediatric Clinics of North America vol. 53 no. 05 (Oct. 2006), page 1029.

Ketersediaan

Perpustakaan FK Nomor Panggil: P13.K.2006.05 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Reactive oxygen species (ROS) are a family of oxygen-derived free radicals that are produced in mammalian cells under normal and pathologic conditions. Many ROS, such as the superoxide anion (O2) and hydrogen peroxide (H2O2), act as cellular signaling molecules within blood vessels, altering mechanisms mediating mechanical signal transduction and autoregulation of cerebral blood flow. This article focuses on the action of ROS, such as O2 and H2O2, and how they infuence mechanisms responsible for the modulation of pressure-induced myogenic tone in the cerebral circulation and blood flow autoregulation in response to elevated arterial pressure. ROS may be a key target for therapeutic interventions in pediatric patients who have hypoxic injury or altered cerebral metabolism induced by trauma or infection.

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