Defects in Surfactant Synthesis: Clinical Implications  

Oleh:

Cole, F. Sessions ; Nogee, Lawrence M. ; Hamvas, Aaron

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Pediatric Clinics of North America vol. 53 no. 05 (Oct. 2006), page 911.

Ketersediaan

Perpustakaan FK Nomor Panggil: P13.K.2006.05 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Since the original desciption of deficiency of the pulmonary surfactant in premature newborn infants by Avery and Mead in 1959, respiratory distress syndrome has most commonly been attributed to developmental immaturity of surfactant production. Studies of different ethnic groups, gender, tergeted gene ablation in murine lineages, and recent clinical reports of monogenic causes of neonatal respiratory distrees syndrome, have demonstrated that genetic defects disrupt pulmonary surfactant metabolism and cause respiratory distress syndrome, especially in term or nearterm infants and in older infants, children, and adults. In contrast to developmental cause of respiratory distress, which may improve as infants and children mature, genetic causes result in both aculate and chronic (and potentially irreversible) respiratory failure.

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