GABARAP: Lessons for Synaptogenesis  

Oleh:

Nikolov, Dimitar B. ; Coyle, Joseph E.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The Neuroscientist vol. 9 no. 3 (Jun. 2003), page 205–216.
Topik: Synapse formation; GABARAP; GABAA receptors; Receptor trafficking
Fulltext: 205TN93.pdf (297.38KB)

Isi artikel

The clustering of neurotransmitter receptors at the postsynaptic terminals is a critical requirement for efficient neurotransmission and neuronal communication. This process is facilitated by adaptor proteins, which bridge the postsynaptic receptors and the underlying cytoskeleton. One such molecule, the GABAA receptor–associated protein, GABARAP, was identified as a potential linker between GABAA receptors and microtubules. GABARAP belongs to an expanding family of proteins that are implicated in a variety of intracellular transport processes. GABARAP has been shown to interact with myriad binding partners, including the ?2 subunit of the GABAA receptor, tubulin and microtubules, the N-ethyl maleimide sensitive factor, gephyrin, and the transferin receptor. The recent determination of the GABARAP crystal structure has revealed individual GABARAP domains, motifs, and surface regions involved in specific protein-protein interactions. Currently, a more general role is emerging for GABARAP, including shipping GABAA receptors to and from the cell surface, organizing them into postsynaptic clusters, and regulating the steady-state receptor density.

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