Controlled Study of Switching From Attention-Deficit / Hyperactivity Disorder to A Prepubertal and Early Adolescent Bipolar I Disorder Phenotype During 6-Year Prospective Folow-Up : Rate , Risk and Predictors  

Oleh:

Tillman, Rebecca ; Geller, Barbara

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Development and Psychopathology vol. 18 no. 4 (2006), page 1037-1054.
Topik: risk; hyperactivity; prepubertal; adolescent; rate; risk; predictors; deficit
Fulltext: 1037.pdf (166.36KB)

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Perpustakaan Pusat (Semanggi) Nomor Panggil: DD21.11 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Rate, risk and predictors of switching from attention - deficit / hyperactivity disorder (ADHD) to a prepubertal and early adolescent bipolar I disorder pehotype (PEA - BP - I) were examined in a blindly rated, controled, prospective 6 - year follow - up that included assessmentas at 2 - year intervals. Subjects were outpatients obtained by consecutive new case ascertainment. There were 81 subjects who were 9.7 ± 2.0 years. Subjects had DSM - IV ADHD (hyperactive or combined subtypes); a Children's Global Assessment Scale (CGAS) score of [less - than - or - equal]60, consistent with moderate – severe impairment; and no BP or major depressive disorder (MDD) diagnoses. PEA - BP - I was defined as DSM - IV BP I (manic or mixed phase), with cardinal symptoms (elation and / or grandiosity), to avoid diagnosing mania by symptoms that overlapped with those of ADHD, and by a CGAS score of [less - than - or - equal] 60. Morbid risk of switching to PEA - BP - I was 28.5%. Significant predictors of switching in a multivariate Cox model were more severe baseline CGAS, paternal recurrent MDD, and less stimulant use. BP I in first - degree relatives, antidepressants, psychosocial measures, and life events were not predictive.

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