Transcriptional Regulation of perinatal Lung Maturation  

Oleh:

Whitsett, Jeffrey A ; Matsuzaki, Yohei

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Pediatric Clinics of North America vol. 53 no. 05 (Oct. 2006), page 873.

Ketersediaan

Perpustakaan FK Nomor Panggil: P13.K.2006.05 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Respiration at birth depends on maturation changes in lung tissue architecture, cell differentiation, and gene expression. At the trensriptional level, maturation is controlled by the actions of group of trascription factors mediating gene expression in the lung. A network of trascription factors regulates gene expression in the respiratoty epithelium, which then influences cell maturation throughout the lung. Glucocorticoids (via the glucocorticoid receptor), acting primarily in the pulmonary mesenchyme, influence maturation in the respiratory epithelium. Elucidation of the intersecting pathways controlling perinatal lung function may provide opportunities to induce pulmonary maturation in preterm infantsat risk for respiratory distress syndrome before birth, and will help identify genes and process important for various aspects of lung function.

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