Calcium Dysregulation in the Aging Brain  

Oleh:

Foster, Thomas C. ; Kumar, Ashok

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The Neuroscientist vol. 8 no. 4 (Agu. 2002), page 297–301.
Topik: Aging; Calcium; Hippocampus; Memory; Synaptic plasticity
Fulltext: 297TN84.pdf (197.52KB)

Isi artikel

The idea that age-related cognitive decline is associated with disruption of calcium (Ca2+) homeostasis has been investigated over the past two decades. Much of this work has focused on the hippocampus because hippocampal- dependent memory is age sensitive. It is now well established that Ca2+-dependent processes such as susceptibility to neurotoxicity, the afterhyperpolarization amplitude, induction of synaptic plasticity, and long-term potentiation and long-term depression are altered with age. Recent work has identified changes in Ca2+ signaling pathways that may underlie the development of these biological markers of aging. This review considers recent findings concerning interactions between the various Ca2+-dependent processes, with special emphasis on the role of altered Ca2+ regulation and disruption of Ca2+ signaling pathways in mediating the expression of biological and behavioral markers of brain aging.

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