A Look to the Future:Prediction,Prevention and Cure Including Islet Transplantation and Stem Cell Therapy  

Oleh:

Casu, Anna ; Trucco, Massimo ; Pietropaolo, Massimo

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Pediatric Clinics of North America vol. 52 no. 06 (Dec. 2005), page 1779.

Ketersediaan

Perpustakaan FK Nomor Panggil: P13.K.2005.06 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Type 1 diabetes mellitus (T1DM) is characterized by the almost complete absence of insulin secretion,which is secondary to an autoimmune destruction or dysfunction of the insulin-producing cells of the pancreatic islets of Langerhans. Because T1DM is an autoimmune disease with a long preclinical course, thepredictive testing of individuals before the clinical onset of the disease has provided a real opportunity for the identification of risk markers and the design of therapeutic intervention. With such a high degree of predictability using a combination of immunologic markers,strategies to prevent T1DM may become possible. A number of novel therapeutic strategies are under investigation in newly diagnosed T1DM patients and might ultimately be applied to prevent T1DM.

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