Therapeutic Antibody Gene Transfer  

Oleh:

Marasco, Wayne A.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Nature Biotechnology: The Science and Business of Biotechnology vol. 23 no. 5 (Mei 2005), page 551.
Topik: gene; therapeutic; antibody; gene transfer

Ketersediaan

Perpustakaan Pusat (Semanggi) Nomor Panggil: NN9.3 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

AAV vectors containing the combined furin site and 2A self cleaving peptide facilitate high level expression of monoclonal antibodies in vivo. The field of human antibody engineering has seen important recent advances, including de novo methods for isolating high affinity human antibodies and the creation of transgenic mice expressing human antiboides. Yet serious bottlenecks in the development process remain, related primarily to the costs and time involved in producing and manufacturing human monoclonal antibodies (mAbs) both at the preclinical and clinical scales...

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