Cell - Specific Targeting of Nano Particles by Multivalent Attachement of Small Molecules  

Oleh:

Weissleder, Ralph ; Kelly, Kimberly ; Sun, Eric Yi ; Shtatland, Timur ; Josephson, Lee

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Nature Biotechnology: The Science and Business of Biotechnology vol. 23 no. 11 (Nov. 2005), page 1418-1423.
Topik: MOLECULE; nanoparticles; multivalent; small molecules

Ketersediaan

Perpustakaan Pusat (Semanggi) Nomor Panggil: NN9.4 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Nanomaterials with precise biological functions have considerable potential for use in biomedical application. Here we investigate whether multivalent attachment of small molecules can increase specific binding affinity and reveal new biological properties of such nanomaterials. We describe the parallel synthesis of a library comprising 146 nanoparticles decorated with different synthethic small molecules. Using fluorescent magnetic nanoparticles, we rapidly screened the library againsts different cell lines and discovered a series of nano particles with high specificity for enfothelial cells, activated human macrophages or pancreatic cancer cells. Hits from the last mentioned screen were shown to target pancreatic cancer in vivo. The method and described materials could facilitate development of functional nano materials for applications such as differentiating cell lines, detecting distinct cellular states and targeting specific cell types.

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali