Functional Annotation and Network Reconstruction Through Cross Platform Integration of Microarray Data  

Oleh:

Zhou, Xianghong Jasmine ; Ming-Chih, J. Kao ; Haiyan, Huang ; Wong, Angela ; Nunez-Iglesias, Juan ; Primig, Michael ; Aparicio, Oscar M. ; Finch, Caleb E. ; Morgan, Todd E. ; Wing, Hung Wong

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Nature Biotechnology: The Science and Business of Biotechnology vol. 23 no. 2 (Feb. 2005), page 238-244.
Topik: network; annotation; network; microarray

Ketersediaan

Perpustakaan Pusat (Semanggi) Nomor Panggil: NN9.2 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

The rapid accumulation of microarray data translates into a need for methods to effectively integrate data generated with different platforms. Here we introduce an approach 2nd order expression analysis, that addresses this challenge by first extracting expression pattern as meta information from each data set (1st order expression analysis) and then analyzing them across multiple data sets, using yeast as a model system, we demonstrate two distict advantages of our approach. We can identify genes of the same function yet without coexpersion patterns and we can elucidate the coopeatibities between transcription factors for regulatory network reconstruction by overcoming a key obstacle, namely the quantification of activities of transcription factors. Experiments reported in the literature and performed in our lab support a significant number of our predictions.

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