Programmbale Ligand - Controlled Riboregulators of Eukaryotic Gene Experssion  

Oleh:

Bayer, Travis S. ; Smolke, Christina D.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Nature Biotechnology: The Science and Business of Biotechnology vol. 23 no. 3 (Mar. 2005), page 337-343.
Topik: Programmable; programmable ligand controlled; riboregulators; eukaryotic gene expression

Ketersediaan

Perpustakaan Pusat (Semanggi) Nomor Panggil: NN9.2 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Recent studies have demonstrated the importance of noncoding RNA elements in regulating gene expression networks. We describe the design of a class of small trans acting RNAs that directly regulate gene expression in a ligand dependent manner. These allosteric riboregulators, which we call anti switches, are made fully tunable and modular by rational design. They offer flexible control strategies by adpoting active or inactive forms in response to ligand binding, depending on their design. They can be tailor made to regulate the expression of target transcripts in response to different cellular effectors. Coupled with in vitro selection technologies for generating nucleid acid ligand binding species antiswitches present a platform for programming cellular behavior and genetic networks with respect to cellular state and environmental stimuli.

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