Looking and Listening to Light : The Evolution of Whole - Body Photonic Imaging  

Oleh:

Weissleder, Ralph ; Ntziachristos, Vasilis ; Ripoll, Jorge ; Wang, Lihong V.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Nature Biotechnology: The Science and Business of Biotechnology vol. 23 no. 3 (Mar. 2005), page 313-320.
Topik: EVOLUTION; evolution; whole body photonic imaging

Ketersediaan

Perpustakaan Pusat (Semanggi) Nomor Panggil: NN9.2 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Optical imaging of the life animals has grown into an important tool in biomedical reasearch as advances in photonic technology and reporter strategies have led to widespread exploration of biological processes in vivo, Although much attention has been paid to microscopy, macrpscopic imaging has allowed small animal imaging with larger fields of view (from several militers to several centimeters depending on implementation). Photographic methods have been the mainstay for fluorescence and bioluminescence macroscopy in whole animals, but emphasis is shifting to photonic methods that use tomographic principles to noninvasively image optical contrast at depths of several milimeters to centimeters with high sensitivity and sub milimeters to centimeters with high sensitivity and sub millimeter to millimeter resolution. Recent theoretical and instrumentation advances allow the use of large data sets and multiple projections and offer practical system, for quantitative, three dimensional whole body images. For photonic imaging to fully realize its potential, however further progress will be needed in refining optical inversion method and data acquisition techniques.

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