Breaking The Barriers to Global Gene Delivery  

Oleh:

Weitzman, Matthew D. ; Thislethwaite, Patricia A.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Nature Biotechnology: The Science and Business of Biotechnology vol. 23 no. 3 (Mar. 2005), page 305.
Topik: barriers; barriers; global gene delivery

Ketersediaan

Perpustakaan Pusat (Semanggi) Nomor Panggil: NN9.2 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Efficient gene delivery to muscles has been achieved with adeno associated virus 8. For both scentist and physician, the bigest challenge to the use of viral vectors for gene delivery is how to introduce and express the therapeutic gene in a sufficient number of cells to achieve clinical efficacy. This is particularly true for the treatment of heart disease and muscular dystrophies. In this issue, wang et al demonstrate remarkable global muscular transduction in rodent models by exploiting the natural diversity present in viral capsids. Efficient transduction is achieved by one sero type of adeno associated virus (AAV), AAV8, suggesting that the barriers to global muscular gene delivery are surmountable by careful selection of the viral serotype.

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