A Simple Method to Cure Established Tumors by Inflammatory Killing of Normal Cells  

Oleh:

Gough, Michael ; Daniels, Gregory A. ; Sanchez-Perez, Luis ; Diaz, Rosa Maria ; Kottke, Timothy ; Thompson, Jill D. ; Lai, Maoyi ; Karim, Mahzuz ; Bushell, Andrew ; Heung Chong ; Melcher, Alan ; Harrington, Kevin ; Vile, Richard G.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Nature Biotechnology: The Science and Business of Biotechnology vol. 22 no. 9 (Sep. 2004), page 1125-1132.
Topik: cells; tumors; inflammatory killing; normal cells

Ketersediaan

Perpustakaan Pusat (Semanggi) Nomor Panggil: NN9.1 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

We describe a simple technology used to cure an established metastatic disease. Intradermal injection of plasmid DNA encoding a transcriptionally targeted cytotoxic gene along with hsp 70, not only promoted tissue specific, inflammatory killing of normal melanocytes, but also induced a CD9+. T-cell dependent, antigen specific response in mice that eradicated systemically established B16 tumors. This CD8 + T cell response was subsequently supressed in vivo within a few days. The data demonstrate that deliberate destruction of normal tissue can be exploited to generate immunity against a malignant disease originating from that tissue. This approach obviates the need to identify tumor antigens and does not require complex isolation of tumor cells or their derivatives. In addition, it provides a model system for studying the mechanisms underlying the etiology and control of autoimmune diseases. Finally, despite targeting normal tissue, therapy could be separated from development of overt autoimmune symptoms, suggesting that the strategy may be valuable against tumors derived from both non essential and essential tissue type.

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